Vulnamin® contains sodium hyaluronate and four synthetic amino acids (glycine, L-leucine, L-proline and L-lysine Hcl).1,2,3,4

Sodium hyaluronate

Sodium hyaluronate is an extracellular polysaccharide and is found in every human tissue and body fluid. It is involved in every phase of tissue repair.5


Hyaluronic acid has been shown to promote cell proliferation, differentiation and motility.6

Amino Acids

Sufficient protein is necessary for wound healing due to increased overall protein need for tissue regeneration and repair. Increased metabolic demands are made by the inflammation and cellular activity in wound healing, which may require increased protein or amino acids, vitamins and minerals.7


Glycine, leucine, proline and lysine may be involved in favouring wound healing by collagenogenesis and extracellular matrix formation.6
It is hypothesised that the availability of amino acids may improve and accelerate wound closure.8

Wound healing


Wound healing can be influenced by a person’s overall health and nutritional status, and can be impeded by several clinically significant factors including hypoxia, infection, tumours, metabolic disorders such as diabetes mellitus, the presence of debris and necrotic tissue, certain medications and a diet deficient in protein, vitamins or minerals.7

Many wound repair processes are common to all tissues9, and seek to restore tissue integrity.10

 

Vulnamin® products

What is
Vulnamin®?

Vulnamin® products are CE marked medical devices that can be used as an adjuvant in the wound healing process.1,2,3,4

Vulnamin® products are available in four presentations: a spray,  a powder, a gel and a cream.1,2

Vulnamin® Spray

Vulnamin® Spray has a preventative effect on the evolution of skin lesions and can be used to protect skin integrity. It facilitates the cleaning of the wound and formation of granulation tissue and therefore skin regeneration.

Vulnamin® Spray additionally reduces inflammatory infiltrate and stimulates fibroblast production of collagen.1

Vulnamin® Powder

Vulnamin® Powder favours production of granulation tissue and the healing process. It assists skin and connective tissue regeneration through the production of collagen.

Vulnamin® Powder favours the elimination of necrotic tissue and protects the integrity of skin.2

Vulnamin® Cream

Vulnamin® cream facilitates regeneration of tissues and maintenance of the ideal moisture conditions of the wound to promote reepithelialisation of cutaneous lesions.

It promotes the reconstruction of connective tissue and therefore the regeneration of epithelial cells.4

Vulnamin® Gel

Vulnamin® Gel can be used to help restore the microenvironment of the wound, promoting elimination of necrotic tissues and protecting skin integrity.

Vulnamin® Gel can be used to induce autolysis and stimulate granulation of vital underlying tissue.3

What effect
does Vulnamin®
have on wound healing?

Vulnamin® induces re-epithelialisation of the wound, which is associated with a marked reduction in inflammatory infiltrate and colonisation of the lesion by newly formed vessels.11

Vulnamin® has been shown to significantly increase the coverage of wounds by granulation tissue12, even whilst debridement is underway.13

The use of Vulnamin® has not been associated with any adverse effects, intolerances or allergies.13

Vulnamin® has been clinically shown to induce a rapid and progressive reduction in wound size, and to reduce healing time of wounds.11,12,13,14

Wound size has been shown to be significantly reduced after 2 weeks of use, with a continued significant reduction after 614 and 10 weeks of use compared to baseline.11